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Version: 17.06d (Release date: 2017-06-26)
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PI3K-delta Inhibitor AMG 319 (Code C95891)

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Terms & Properties

Preferred Name: PI3K-delta Inhibitor AMG 319

Definition: A highly selective, potent, and orally bioavailable small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. PI3K-delta inhibitor AMG 319 prevents the activation of the PI3K signaling pathway through inhibition of the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), thus decreasing proliferation and inducing cell death. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.

Display Name: PI3K-delta Inhibitor AMG 319

Label: PI3K-delta Inhibitor AMG 319

NCI Thesaurus Code: C95891 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428288  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMG 319
PI3K-delta Inhibitor AMG 319

External Source Codes: 
PDQ Closed Trial Search ID 696292
PDQ Open Trial Search ID 696292 (check for NCI PDQ open clinical trial info)
NCI META CUI CL428288

Other Properties:
     Name Value (qualifiers indented underneath)
code C95891
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95891

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