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Version: 17.06d (Release date: 2017-06-26)
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STAT3 Inhibitor OPB-51602 (Code C95889)

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Terms & Properties

Preferred Name: STAT3 Inhibitor OPB-51602

Definition: An orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. STAT3 inhibitor OPB-51602 inhibits the phosphorylation and thus the activation of STAT3 protein, impeding STAT3 protein from translocating from the cytoplasm to the nucleus and thereby blocking STAT3's regulation of gene expression through direct binding to the promoters of responsive genes. STAT3 regulates the cellular functions that lead to the cancer phenotype, and constitutive activation of STAT3 is observed in a wide range of human cancers, inducing uncontrolled proliferation and neoplastic transformation.

Display Name: STAT3 Inhibitor OPB-51602

Label: STAT3 Inhibitor OPB-51602

NCI Thesaurus Code: C95889 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428286  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
OPB-51602
STAT3 Inhibitor OPB-51602

External Source Codes: 
PDQ Closed Trial Search ID 684303
PDQ Open Trial Search ID 684303 (check for NCI PDQ open clinical trial info)
NCI META CUI CL428286

Other Properties:
     Name Value (qualifiers indented underneath)
code C95889
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95889

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