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Version: 17.08d (Release date: 2017-08-28)
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Carbon C 11 Alpha-methyltryptophan (Code C95887)

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Terms & Properties

Preferred Name: Carbon C 11 Alpha-methyltryptophan

Definition: A radiopharmaceutical containing an analogue of tryptophan, alpha-methyltryptophan (AMT), labeled with carbon 11 (11C), used to measure serotonin synthesis in the human brain using positron emission tomography (PET). Upon administration and once it crosses the blood-brain barrier and into the cytoplasm of serotonergic neurons, carbon C 11 alpha-methyltryptophan acts as a substrate for the enzyme tryptophan hydroxylase and undergoes conversion to carbon C 11 alpha-methyl-5-hydroxytryptophan, also known as C 11 alpha-methyl-serotonin (AMS). C 11 AMS accumulates in serotonergic nerve terminals in proportion to the synthesis rate of serotonin because C 11 AMS cannot be broken down by the enzyme monoamine oxidase, and thus the synthesis rate of serotonin can be imaged using PET. C 11 AMT is not incorporated into proteins, nor are metabolites released into the blood pool, making C 11 AMT an excellent tracer for serotonin synthesis in vivo.

Display Name: Carbon C 11 Alpha-methyltryptophan

Label: Carbon C 11 Alpha-methyltryptophan

NCI Thesaurus Code: C95887 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1671973  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
11C-alpha-methyltryptophan
11C-AMT
[11C] AMT
alpha-[11C]methyl-L-tryptophan
Carbon C 11 Alpha-methyltryptophan

External Source Codes: 
PDQ Closed Trial Search ID 695985
PDQ Open Trial Search ID 695985 (check for NCI PDQ open clinical trial info)
UMLS CUI C1671973

Other Properties:
     Name Value (qualifiers indented underneath)
code C95887
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95887

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