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Version: 16.11d (Release date: 2016-11-28)
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Edatrexate (Code C958)

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Terms & Properties

Preferred Name: Edatrexate

Definition: A polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to a family of drugs called antimetabolites.

Label: Edatrexate

NCI Thesaurus Code: C958 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0044667  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
10-EDAM
10-EdAM
10-Ethyl-10-deaza-aminopterin
CGP-30694
EDAM
EDATREXATE
Edatrexate
edatrexate
N-[4-[1-[(2,4-Diamino-6-pteridinyl)-methyl]propyl]benzoyl]-L-glutamic Acid
N-[4-[1-[(2, 4-Diamino-6-pteridinyl)-methyl]propyl]benzoyl]-L-glutamic acid

External Source Codes: 
CAS Registry Number 80576-83-6 (see NLM ChemIDplus info)
FDA UNII Code JT4X6Z1HRR
NSC Code 626715 (see NCI DTP info)
PDQ Closed Trial Search ID 40887
PDQ Open Trial Search ID 40887 (check for NCI PDQ open clinical trial info)
UMLS CUI C0044667

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C22H25N7O5
code C958
Contributing_Source FDA
Legacy_Concept_Name Edatrexate
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C958

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