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Version: 17.06d (Release date: 2017-06-26)
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siG12D LODER (Code C95772)

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Terms & Properties

Preferred Name: siG12D LODER

Definition: A proprietary, miniature biodegradable polymeric matrix containing small-interfering RNAs for the mutated KRAS oncogene, KRASG12D, (siG12D), with potential antitumor activity. Upon intratumoral injection, this siG12D is released locally, thereby preventing translation of KRAS proteins and potentially inhibiting growth of tumor cells overexpressing KRAS. KRAS, a member of the small GTPase superfamily, is mutated in over 90% of human pancreatic ductal adenocarcinomas (PDAC) and is associated with tumor cell proliferation and reduced survival.

Label: siG12D LODER

NCI Thesaurus Code: C95772 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428214  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
siG12D LODER

External Source Codes: 
PDQ Closed Trial Search ID 685237
PDQ Open Trial Search ID 685237 (check for NCI PDQ open clinical trial info)
NCI META CUI CL428214

Other Properties:
     Name Value (qualifiers indented underneath)
code C95772
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95772

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