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Version: 16.11d (Release date: 2016-11-28)
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ULvWF Multimer-targeting Agent ARC1779 (Code C95742)

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Terms & Properties

Preferred Name: ULvWF Multimer-targeting Agent ARC1779

Definition: An optimized, second-generation, PEGylated aptamer with antithrombotic property. ULvWF multimer-targeting agent ARC1779 blocks the binding of von Willebrand factor (vWF), via the A1 domain, and ultra-large vWF multimers to platelets, as well as interferes with the binding of platelet receptor glycoprotein Ib, thus reducing platelet adhesion, aggregation and thrombus growth in arterial beds. Unlike other antiplatelet agents, this aptamer can be readily reversed by binding to a complementary sequence of oligonucleotides, and may therefore offer potential therapeutic benefit in surgery.

Display Name: ULvWF Multimer-targeting Agent ARC1779

Label: ULvWF Multimer-targeting Agent ARC1779

NCI Thesaurus Code: C95742 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2351141  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ARC1779
ULvWF Multimer-targeting Agent ARC1779

External Source Codes: 
PDQ Closed Trial Search ID 694584
PDQ Open Trial Search ID 694584 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 19479665 (see PubMed Primary Reference info)
UMLS CUI C2351141

Other Properties:
Name Value (qualifiers indented underneath)
code C95742
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95742

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