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Version: 16.10e (Release date: 2016-10-31)
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eIF4E Antisense Oligonucleotide ISIS 183750 (Code C95740)

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Terms & Properties

Preferred Name: eIF4E Antisense Oligonucleotide ISIS 183750

Definition: A second-generation antisense oligonucleotide targeting the eukaryotic translation initiation factor 4E (eIF4E) with potential antitumor activity. Antisense oligonucleotide ISIS EIF4ERx suppresses the expression of eIF4E in fast dividing tumor cells. Blocking the expression of eIF4E results in inhibition of the synthesis of tumor angiogenic factors, thereby leading to the inhibition of cellular proliferation and apoptosis in tumor cells. eIF4E is overexpressed in a variety of cancers, is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis and is the rate-limiting component of the eukaryotic translation apparatus.

Display Name: eIF4E Antisense Oligonucleotide ISIS 183750

Label: eIF4E Antisense Oligonucleotide ISIS 183750

NCI Thesaurus Code: C95740 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987390  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
eIF4E Antisense Oligonucleotide ISIS 183750
eIF4E Inhibitor ISIS 183750
eIF4E Modulator ISIS 183750
ISIS 183750
LY2275796

External Source Codes: 
PDQ Closed Trial Search ID 680421
PDQ Open Trial Search ID 680421 (check for NCI PDQ open clinical trial info)
UMLS CUI C2987390

Other Properties:
Name Value (qualifiers indented underneath)
code C95740
Contributing_Source CTRP
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95740

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