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Version: 17.06d (Release date: 2017-06-26)
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MEK Inhibitor GDC-0623 (Code C95738)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: MEK Inhibitor GDC-0623

Definition: An orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

Display Name: MEK Inhibitor GDC-0623

Label: MEK Inhibitor GDC-0623

NCI Thesaurus Code: C95738 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421583  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GDC-0623
MEK Inhibitor GDC-0623

External Source Codes: 
PDQ Closed Trial Search ID 673612
PDQ Open Trial Search ID 673612 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421583

Other Properties:
     Name Value (qualifiers indented underneath)
code C95738
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95738

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