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Version: 17.06d (Release date: 2017-06-26)
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Akt Inhibitor LY2780301 (Code C95737)

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Terms & Properties

Preferred Name: Akt Inhibitor LY2780301

Definition: An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Label: Akt Inhibitor LY2780301

NCI Thesaurus Code: C95737 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421578  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Akt Inhibitor LY2780301
LY2780301

External Source Codes: 
PDQ Closed Trial Search ID 673505
PDQ Open Trial Search ID 673505 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421578

Other Properties:
     Name Value (qualifiers indented underneath)
code C95737
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95737

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