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Version: 17.06d (Release date: 2017-06-26)
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Talazoparib (Code C95733)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Talazoparib

Definition: An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.

Display Name: Talazoparib

Label: Talazoparib

NCI Thesaurus Code: C95733 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C4042960  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMN-673
BMN 673
Talazoparib

External Source Codes: 
PDQ Closed Trial Search ID 694964
PDQ Open Trial Search ID 694964 (check for NCI PDQ open clinical trial info)
UMLS CUI C4042960

Other Properties:
     Name Value (qualifiers indented underneath)
code C95733
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95733

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