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Version: 17.06d (Release date: 2017-06-26)
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Merestinib (Code C95729)

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Terms & Properties

Preferred Name: Merestinib

Definition: An orally available, small molecule inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. Merestinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. This agent has potent anti-tumor efficacy in mono and combination therapy in a broad range of cancers. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

Display Name: Merestinib

Label: Merestinib

NCI Thesaurus Code: C95729 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987379  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-Pyridinecarboxamide, N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-
LY-2801653
LY2801653
Merestinib
MERESTINIB

External Source Codes: 
CAS Registry Number 1206799-15-6 (see NLM ChemIDplus info)
FDA UNII Code 5OGS5K699E
PDQ Closed Trial Search ID 694732
PDQ Open Trial Search ID 694732 (check for NCI PDQ open clinical trial info)
UMLS CUI C2987379

Other Properties:
     Name Value (qualifiers indented underneath)
code C95729
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95729

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