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Version: 17.06d (Release date: 2017-06-26)
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Carbon C 11 N-desmethyl-Loperamide (Code C95725)

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Terms & Properties

Preferred Name: Carbon C 11 N-desmethyl-Loperamide

Definition: A radiopharmaceutical containing N-desmethyl loperamide (dLop) labeled with carbon 11 (11C), used to measure the activity of efflux transporter P-glycoprotein (P-gp) in positron emission tomography (PET). Upon administration, carbon C 11 N-desmethyl-loperamide acts as a substrate for the efflux transporter P-gp. Upon uptake by P-gp at the blood-brain barrier (BBB) and subsequent PET imaging, this radioligand may allow for prediction of P-gp function and expression in brain tumor patients. As P-gp activity may influence response to therapy, measuring P-gp activity may be beneficial when choosing chemotherapy. P-gp, encoded by the MDR-1 gene and a member of the ATP-binding cassette (ABC) superfamily of transmembrane transporters, is overexpressed by some MDR tumors and may contribute to multidrug resistance to chemotherapy.

Label: Carbon C 11 N-desmethyl-Loperamide

NCI Thesaurus Code: C95725 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3816741  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Carbon C 11 N-desmethyl-Loperamide

External Source Codes: 
PDQ Closed Trial Search ID 694530
PDQ Open Trial Search ID 694530 (check for NCI PDQ open clinical trial info)
UMLS CUI C3816741

Other Properties:
     Name Value (qualifiers indented underneath)
code C95725
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  


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