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Version: 17.06d (Release date: 2017-06-26)
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PI3K Inhibitor ZSTK474 (Code C95723)

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Terms & Properties

Preferred Name: PI3K Inhibitor ZSTK474

Definition: An orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor ZSTK474 inhibits all four PI3K isoforms. Inhibiting the activation of the PI3K/AKT kinase (or protein kinase B) signaling pathway results in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. This agent does not induce apoptosis but rather induces strong G(0)/G(1) arrest, which might contribute to its favorable efficacy in tumor cells.

Display Name: PI3K Inhibitor ZSTK474

Label: PI3K Inhibitor ZSTK474

NCI Thesaurus Code: C95723 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1721602  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Phosphatidylinositol 3-kinase Inhibitor ZSTK474
PI3K Inhibitor ZSTK474
ZSTK474

External Source Codes: 
FDA UNII Code K0068GK39A
PDQ Closed Trial Search ID 694436
PDQ Open Trial Search ID 694436 (check for NCI PDQ open clinical trial info)
UMLS CUI C1721602

Other Properties:
     Name Value (qualifiers indented underneath)
code C95723
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95723

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