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Version: 17.06d (Release date: 2017-06-26)
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Liposomal c-raf Antisense Oligonucleotide (Code C95718)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Liposomal c-raf Antisense Oligonucleotide

Definition: The liposomal formulation of a c-raf-1 antisense oligonucleotide, with potential antineoplastic activity. Liposomal c-raf antisense oligonucleotide targets the translation initiation site of human c-raf-1 mRNA, thereby blocking the expression and production of Raf-1 protein and thus inhibit tumor cell growth and development. Raf-1 plays a key role in the RAF/MEK/ERK signaling pathway, which regulates mammalian cell proliferation and growth. The liposomal formulation increases the solubility of the c-raf antisense oligonucleotide, thus improving its pharmacodynamic profile.

Label: Liposomal c-raf Antisense Oligonucleotide

NCI Thesaurus Code: C95718 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1436330  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
c-raf Antisense Oligodeoxynucleotide Liposome
LErafAON
Liposomal c-raf Antisense Oligonucleotide
liposome-encapsulated c-raf Antisense Oligodeoxynucleotide

External Source Codes: 
PDQ Closed Trial Search ID 419645
PDQ Open Trial Search ID 419645 (check for NCI PDQ open clinical trial info)
UMLS CUI C1436330

Other Properties:
     Name Value (qualifiers indented underneath)
code C95718
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95718

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