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Version: 17.06d (Release date: 2017-06-26)
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Liposomal SN-38 (Code C95717)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Liposomal SN-38

Definition: The liposomal formulation of SN-38 (7-ethyl-10-hydroxy-camptothecin), a biologically active metabolite of the prodrug irinotecan, with potential antineoplastic activity. SN-38 binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis. SN-38 has been reported to exhibit up to 1,000-fold more cytotoxic activity against various cancer cells in vitro than irinotecan. The liposomal formulation of SN-38 increases the solubility of SN-38, which is a relatively insoluble compound, and improves the pharmacodynamic profile as compared to SN-38 alone.

Label: Liposomal SN-38

NCI Thesaurus Code: C95717 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328201  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
7-Ethyl-10-hydroxycamptothecin Liposome
LE-SN38
Liposomal SN-38
SN-38 Liposome

External Source Codes: 
PDQ Closed Trial Search ID 355805
PDQ Open Trial Search ID 355805 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328201

Other Properties:
     Name Value (qualifiers indented underneath)
code C95717
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95717

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