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Version: 17.12d (Release date: 2017-12-26)
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Z-Endoxifen Hydrochloride (Code C95713)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Z-Endoxifen Hydrochloride

Definition: The hydrochloride salt and the z (cis-) stereoisomer of endoxifen with potential antineoplastic activity. Endoxifen, the active metabolite of tamoxifen, competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA and thus reducing DNA synthesis. Unlike tamoxifen, however, which relies on CYP2D6 activity for its conversion to the active metabolite endoxifen, the direct administration of endoxifen bypasses the CYP2D6 route. As CYP2D6 activity can vary widely among individuals due to genetic CYP2D6 polymorphisms, endoxifen is therefore theoretically more potent and more uniform in its bioavailability across patient populations.

Display Name: Z-Endoxifen Hydrochloride

Label: Z-Endoxifen Hydrochloride

NCI Thesaurus Code: C95713 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428178  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Hydroxy-N-Desmethyltamoxifen Hydrochloride
Z-Endoxifen HCl
Z-Endoxifen Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 693335
PDQ Open Trial Search ID 693335 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C95713
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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