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Version: 17.06d (Release date: 2017-06-26)
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Nesvacumab (Code C95712)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nesvacumab

Definition: A fully human monoclonal antibody directed against angiopoietin 2 (ANG2) with potential antiangiogenic and antineoplastic activities. Nesvacumab binds to ANG2 and interferes with the interaction between Ang2 and its receptor TEK tyrosine kinase (Tie2), which may inhibit tumor cell angiogenesis and tumor cell proliferation. ANG2 is upregulated in a variety of cancer cell types and plays a crucial role in angiogenesis.

Label: Nesvacumab

NCI Thesaurus Code: C95712 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428177  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-ANG2 MOAB REGN910
Nesvacumab
REGN910
SAR307746

External Source Codes: 
CAS Registry Number 1296818-77-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 693224
PDQ Open Trial Search ID 693224 (check for NCI PDQ open clinical trial info)
NCI META CUI CL428177

Other Properties:
     Name Value (qualifiers indented underneath)
code C95712
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95712

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