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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 124-labeled Hsp90 Inhibitor PUH71 (Code C95711)

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Terms & Properties

Preferred Name: Iodine I 124-labeled Hsp90 Inhibitor PUH71

Definition: A radioconjugate containing the purine scaffold heat shock protein 90 (Hsp90) inhibitor PUH71 labeled with the radioisotope iodine I 124, with positron emitting activity. Hsp90 inhibitor PUH71 is thought to bind to cytosolic Hsp90 and the endoplasmic reticulum paralogue gp96 (HSP90B1), thereby inhibiting its molecular chaperone function and promoting the degradation of the oncogenic signaling proteins. This induces caspase-dependent apoptosis. The iodine I 124 moiety can be visualized using Positron emission tomography (PET) imaging, thereby allowing an assessment of the accumulation of PUH71 in vivo, particularly in tumors. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins.

Display Name: Iodine I 124-labeled Hsp90 Inhibitor PUH71

Label: Iodine I 124-labeled Hsp90 Inhibitor PUH71

NCI Thesaurus Code: C95711 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987351  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
124I-PUH71
Iodine I 124-labeled Hsp90 Inhibitor PUH71
Iodine I 124 PUH71

External Source Codes: 
PDQ Closed Trial Search ID 692725
PDQ Open Trial Search ID 692725 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 20977755 (see PubMed Primary Reference info)
UMLS CUI C2987351

Other Properties:
     Name Value (qualifiers indented underneath)
code C95711
Contributing_Source CTRP
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95711

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