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Version: 17.06d (Release date: 2017-06-26)
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Palifosfamide Tromethamine (Code C95703)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Palifosfamide Tromethamine

Definition: A synthetic mustard compound of the tromethamine (tris) salt of palifosfamide (Isophosphamide mustard), with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide irreversibly alkylates and crosslinks DNA through GC base pairs, resulting in irreparable 7-atom interstrand crosslinks. This leads to an inhibition of DNA replication and ultimately cell death. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities. In addition, because palifosfamide does not require activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with ifosfamide. Stabilization with tris instead of lysine further increases stability and may further decrease nephrotoxicity.

Display Name: Palifosfamide Tromethamine

Label: Palifosfamide Tromethamine

NCI Thesaurus Code: C95703 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987344  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Palifosfamide Tris
Palifosfamide Tromethamine

External Source Codes: 
PDQ Closed Trial Search ID 689807
PDQ Open Trial Search ID 689807 (check for NCI PDQ open clinical trial info)
UMLS CUI C2987344

Other Properties:
     Name Value (qualifiers indented underneath)
code C95703
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95703

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