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Version: 17.12d (Release date: 2017-12-26)
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JAK2 Inhibitor BMS-911543 (Code C95702)

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Terms & Properties

Preferred Name: JAK2 Inhibitor BMS-911543

Definition: An orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS-911543 selectively inhibits JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.

Display Name: JAK2 Inhibitor BMS-911543

Label: JAK2 Inhibitor BMS-911543

NCI Thesaurus Code: C95702 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987343  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS 911543
JAK2 Inhibitor BMS-911543

External Source Codes: 
FDA UNII Code 7N03P021J8
PDQ Closed Trial Search ID 689517
PDQ Open Trial Search ID 689517 (check for NCI PDQ open clinical trial info)
UMLS CUI C2987343

Other Properties:
     Name Value (qualifiers indented underneath)
code C95702
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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