skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
TLR7 Agonist ANA773 Tosylate (Code C95699)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: TLR7 Agonist ANA773 Tosylate

Definition: The tosylate salt form of ANA773, a Toll-Like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration, ANA773 is metabolized into its active form that binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and enhancing natural killer cell (NK) cytotoxicity. This activation results in the production of proinflammatory cytokines, including interferon alpha, and enhanced antibody-dependent cellular cytotoxicity (ADCC). TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.

Display Name: TLR7 Agonist ANA773 Tosylate

Label: TLR7 Agonist ANA773 Tosylate

NCI Thesaurus Code: C95699 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL428165  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ANA773 Tosylate
TLR7 Agonist ANA773 Tosylate
Toll-Like Receptor 7 Agonist ANA773 Tosylate

External Source Codes: 
PDQ Closed Trial Search ID 689123
PDQ Open Trial Search ID 689123 (check for NCI PDQ open clinical trial info)
NCI META CUI CL428165

Other Properties:
     Name Value (qualifiers indented underneath)
code C95699
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95699

Mainbox Bottom