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Version: 17.06d (Release date: 2017-06-26)
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Allogeneic Renal Cell Carcinoma Vaccine MGN1601 (Code C95213)

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Terms & Properties

Preferred Name: Allogeneic Renal Cell Carcinoma Vaccine MGN1601

Definition: A whole cell vaccine comprised of irradiated allogeneic renal cell carcinoma (RCC) with potential immunostimulating and antineoplastic activities. Allogeneic renal cell carcinoma vaccine MGN1601 contains two active ingredients: 1) genetically modified allogeneic RCC cells that are transiently transfected with four different MIDGE (Minimalistic Immunogenically Defined Gene Expression) vectors encoding IL-7, GM-CSF, CD80 and CD154 and 2) the synthetic DNA-based immunomodulator dSLIM-30L1, a TLR9 agonist.. Vaccination results in expression of IL-7, GM-CSF, CD80 and CD154, which all contribute to the activation or enhancement of immune responses. Furthermore, administration of this RCC vaccine may elicit a cytotoxic T lymphocyte (CTL) response against similar host tumor cells, resulting in decreased tumor growth. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.

Label: Allogeneic Renal Cell Carcinoma Vaccine MGN1601

NCI Thesaurus Code: C95213 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426701  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic Renal Cell Carcinoma Vaccine MGN1601
IL-7/GM-CSF/CD80/CD154-encoding Synthetic dSLIM-30L1 Allogeneic Renal Cell Carcinoma Vaccine MGN1601
MGN1601

External Source Codes: 
PDQ Closed Trial Search ID 692088
PDQ Open Trial Search ID 692088 (check for NCI PDQ open clinical trial info)
NCI META CUI CL426701

Other Properties:
     Name Value (qualifiers indented underneath)
code C95213
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95213

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