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Version: 17.06d (Release date: 2017-06-26)
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Guadecitabine (Code C95209)

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Terms & Properties

Preferred Name: Guadecitabine

Definition: A dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, guadecitabine inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation, and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra and intracellularly, leading to more prolonged exposures to decitabine.

Display Name: Guadecitabine

Label: Guadecitabine

NCI Thesaurus Code: C95209 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2986994  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DNMT inhibitor SGI-110

External Source Codes: 
PDQ Closed Trial Search ID 691684
PDQ Open Trial Search ID 691684 (check for NCI PDQ open clinical trial info)
UMLS CUI C2986994

Other Properties:
     Name Value (qualifiers indented underneath)
code C95209
Contributing_Source CTRP
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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