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Version: 17.06d (Release date: 2017-06-26)
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c-Met Inhibitor AMG 337 (Code C95203)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: c-Met Inhibitor AMG 337

Definition: An orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.

Display Name: c-Met Inhibitor AMG 337

Label: c-Met Inhibitor AMG 337

NCI Thesaurus Code: C95203 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426693  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMG337
AMG 337
c-Met Inhibitor AMG 337

External Source Codes: 
PDQ Closed Trial Search ID 690935
PDQ Open Trial Search ID 690935 (check for NCI PDQ open clinical trial info)
NCI META CUI CL426693

Other Properties:
     Name Value (qualifiers indented underneath)
code C95203
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95203

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