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Version: 17.12d (Release date: 2017-12-26)
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Carbon C-13 Dextromethorphan (Code C95199)

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Terms & Properties

Preferred Name: Carbon C-13 Dextromethorphan

Definition: A radioconjugate consisting of dextromethorphan, a synthetic, methylated dextrorotatory analogue of levorphanol, conjugated with carbon-13 [(13)C] with radiotracer activity. (13)C-dextromethorphan can be used in a breath-test phenotype assay of CYP2D6 activity, based on the principle that CYP2D6-mediated O-demethylation cleaves a (13)CH3 that enters the body's carbon pool to be eliminated ultimately as (13)CO2 in expired air, which can be measured. The (13)C-dextromethorphan breath test may prove useful in identifying poor CYP2D6 metabolizers of such important clinical drugs as tamoxifen.

Label: Carbon C-13 Dextromethorphan

NCI Thesaurus Code: C95199 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426690  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Carbon C-13 Dextromethorphan

External Source Codes: 
PDQ Closed Trial Search ID 690031
PDQ Open Trial Search ID 690031 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C95199
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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