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Version: 16.11d (Release date: 2016-11-28)
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Carbon C-13 Dextromethorphan (Code C95199)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Carbon C-13 Dextromethorphan

Definition: A radioconjugate consisting of dextromethorphan, a synthetic, methylated dextrorotatory analogue of levorphanol, conjugated with carbon-13 [(13)C] with radiotracer activity. (13)C-dextromethorphan can be used in a breath-test phenotype assay of CYP2D6 activity, based on the principle that CYP2D6-mediated O-demethylation cleaves a (13)CH3 that enters the body's carbon pool to be eliminated ultimately as (13)CO2 in expired air, which can be measured. The (13)C-dextromethorphan breath test may prove useful in identifying poor CYP2D6 metabolizers of such important clinical drugs as tamoxifen.

Label: Carbon C-13 Dextromethorphan

NCI Thesaurus Code: C95199 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426690  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
13C-dextromethorphan
[(13)C]-DM
Carbon C-13 Dextromethorphan

External Source Codes: 
PDQ Closed Trial Search ID 690031
PDQ Open Trial Search ID 690031 (check for NCI PDQ open clinical trial info)
NCI META CUI CL426690

Other Properties:
Name Value (qualifiers indented underneath)
code C95199
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95199

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