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Version: 17.12d (Release date: 2017-12-26)
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Vosaroxin (Code C95148)

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Terms & Properties

Preferred Name: Vosaroxin

Definition: A small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, hence reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure.

Display Name: Vosaroxin

Label: Vosaroxin

NCI Thesaurus Code: C95148 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1451341  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
SPC 595

External Source Codes: 
CAS Registry Number 175414-77-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 393833
PDQ Open Trial Search ID 393833 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 20233886 (see PubMed Primary Reference info)
UMLS CUI C1451341

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H19N5O4S
code C95148
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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