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Version: 17.06d (Release date: 2017-06-26)
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Macimorelin (Code C95123)

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Terms & Properties

Preferred Name: Macimorelin

Definition: An orally available synthetic mimetic of the growth hormone (GH) secretagogue ghrelin with potential anti-cachexia activity. Upon oral administration, macimorelin mimics endogenous ghrelin by stimulating appetite and binds to the growth hormone secretagogue receptor GHSR in the central nervous system, thereby mimicking the GH-releasing effects of ghrelin from the pituitary gland. Stimulation of GH secretion increases insulin-like growth factor-I (IGF-I) levels which may further stimulate protein synthesis. In addition, ghrelin reduces the production of pro-inflammatory cytokines, which may play a direct role in cancer-related loss of appetite.

Display Name: Macimorelin

Label: Macimorelin

NCI Thesaurus Code: C95123 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2986922  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AEZS-130
D-Tryptophanamide,2-methylalanyl-N-[(1R)-1-(formylamino)-2-(1H-indol-3-yl)ethyl]-
EP 1572
JMV 1843
Macimorelin
MACIMORELIN
Solorel

External Source Codes: 
CAS Registry Number 381231-18-1 (see NLM ChemIDplus info)
FDA UNII Code 8680B21W73
PDQ Closed Trial Search ID 735530
PDQ Open Trial Search ID 735530 (check for NCI PDQ open clinical trial info)
UMLS CUI C2986922

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H30N6O3
code C95123
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95123

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