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Version: 17.06d (Release date: 2017-06-26)
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Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes (Code C95080)

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Terms & Properties

Preferred Name: Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes

Definition: A population of T lymphocytes polarized by rapamycin with potential immunomodulating activity. The autologous T cells collected from the patient were co-stimulated with antibodies to the T-cell cell surface proteins CD3 and CD28 and expanded ex vivo in the presence of rapamycin, an immunosuppressive drug, and then infused back into the same patient. Both CD3 and CD28 are required for full T-cell activation. These lymphocytes expressed anti-apoptotic bcl-2 family member proteins (reduced Bax, Bak; increased phospho-Bad); maintained mitochondrial membrane potentials; and displayed reduced apoptosis. Adoptive transfer of this type of T cell potentially induces an anti-apoptotic Th1/Tc1 effector phenotype by promoting autophagy.

Display Name: Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes

Label: Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes

NCI Thesaurus Code: C95080 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426578  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ex vivo anti-CD3/CD28 Costimulated, Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes
Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 689637
PDQ Open Trial Search ID 689637 (check for NCI PDQ open clinical trial info)
NCI META CUI CL426578

Other Properties:
     Name Value (qualifiers indented underneath)
code C95080
Contributing_Source CTRP
Semantic_Type Cell

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95080

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