skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Tegafur-Uracil (Code C9506)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Tegafur-Uracil

Definition: A formulated therapeutic oral agent consisting of a combination of the 5-fluorouracil (5-FU) congener prodrug tegafur (tetrahydrofuranyl-5-fluorouracil) and uracil (1:4). The high concentration of uracil reversibly inhibits the uracil-reducing enzyme dihydropyrimidine dehydrogenase (DPD), thereby inhibiting first-pass DPD-mediated hepatic metabolism of the uracil analogue 5-FU and permitting administration of 5-FU as the orally bioavailable prodrug tegafur. Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. It is a combination of tegafur and uracil. The tegafur is taken up by the cancer cells and breaks down into 5-FU, a substance that kills tumor cells. The uracil causes higher amounts of 5-FU to stay inside the cells and kill them. Tegafur-uracil is a type of antimetabolite.

Label: Tegafur-Uracil

NCI Thesaurus Code: C9506 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1446539  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oral Fluorouracil-Uracil
tegafur-uracil
Tegafur-Uracil
UFT
Uftoral
Uracil/Tegafur (UFT)
Uracil and Ftorafur
Uracil and Tegafur
Uracil and Tetrahydrofuranyl-5-Fluorouracil

External Source Codes: 
NSC Code 719164 (see NCI DTP info)
PDQ Closed Trial Search ID 461135
PDQ Open Trial Search ID 461135 (check for NCI PDQ open clinical trial info)
UMLS CUI C1446539

Other Properties:
     Name Value (qualifiers indented underneath)
code C9506
Legacy_Concept_Name Tegafur_Uracil
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C9506

Mainbox Bottom