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Version: 17.06d (Release date: 2017-06-26)
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Y-shape Branched Pegylated Filgrastim (Code C95026)

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Terms & Properties

Preferred Name: Y-shape Branched Pegylated Filgrastim

Definition: A long-acting, pegylated variant of filgrastim (recombinant human granulocyte colony-stimulating factor (G-CSF)) with immunomodulating activity. Similar to endogenous G-CSF, this agent binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. The modification of this version of filgrastim with the addition of a Y-shaped branch of polyethylene glycol at a specific lysine residue (Lys 17) theoretically serves to extend the half-life of the agent.

Label: Y-shape Branched Pegylated Filgrastim

NCI Thesaurus Code: C95026 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426560  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Y-shape Branched Pegylated Filgrastim
YPEG-filgrastim
YPEG-rhG-CSF

External Source Codes: 
PDQ Closed Trial Search ID 689331
PDQ Open Trial Search ID 689331 (check for NCI PDQ open clinical trial info)
NCI META CUI CL426560

Other Properties:
     Name Value (qualifiers indented underneath)
code C95026
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95026

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