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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 131 Monoclonal Antibody F16SIP (Code C95025)

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Terms & Properties

Preferred Name: Iodine I 131 Monoclonal Antibody F16SIP

Definition: A fully human monoclonal antibody (MoAb) against human A1 domain of tenascin-C, in small immunoprotein (SIP) format conjugated with iodine 131 with potential antineoplastic activity. Iodine I 131 MoAb F16SIP binds to tenascin-C on the vascular tissues and delivers cytotoxic radiation to the tumors, thereby minimizing systemic radiotoxicity. Tenascin-C is a glycoprotein of the extracellular matrix, and the large isoform of this matrix protein is expressed and restricted around vascular structures in the tumor stroma of a variety of different tumors.

Label: Iodine I 131 Monoclonal Antibody F16SIP

NCI Thesaurus Code: C95025 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2986856  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(131I) Monoclonal Antibody F16SIP
131I-F16SIP
F16-131I
Iodine I 131 Monoclonal Antibody F16SIP
Tenarad

External Source Codes: 
PDQ Closed Trial Search ID 689747
PDQ Open Trial Search ID 689747 (check for NCI PDQ open clinical trial info)
UMLS CUI C2986856

Other Properties:
     Name Value (qualifiers indented underneath)
code C95025
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95025

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