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Version: 16.10e (Release date: 2016-10-31)
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Cinobufagin (Code C95021)

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Terms & Properties

Preferred Name: Cinobufagin

Definition: A bufadienolide compound extracted from the dried venom secreted by the parotid glands of toads and one of the glycosides in the traditional Chinese medicine ChanSu, with potential antineoplastic activity. Although the mechanism of action of cinobufagin is still under investigation, it has been found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators that include mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9. Possible upstream mediators of cinobufagin-induced apoptosis include Fas and p53.

Label: Cinobufagin

NCI Thesaurus Code: C95021 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0055767  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cinobufacini
Cinobufagin

External Source Codes: 
PDQ Closed Trial Search ID 689412
PDQ Open Trial Search ID 689412 (check for NCI PDQ open clinical trial info)
UMLS CUI C0055767

Other Properties:
Name Value (qualifiers indented underneath)
code C95021
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95021

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