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Version: 17.06d (Release date: 2017-06-26)
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Lutetium Lu 177-DOTA-TATE (Code C95020)

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Terms & Properties

Preferred Name: Lutetium Lu 177-DOTA-TATE

Definition: A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope lutetium Lu 177, with potential imaging and antineoplastic activities. Lutetium Lu 177-DOTA-TATE binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor (NET) cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. Tyr3-octreotate (TATE) is an octreotide derivative in which phenylalanine at position 3 is substituted by tyrosine and position 8 threoninol is replaced with threonine. SSTRs have been shown to be present in large numbers on NET and their metastases, while most other normal tissues express low levels of SSTRs.

Display Name: Lutetium Lu 177-DOTA-TATE

Label: Lutetium Lu 177-DOTA-TATE

NCI Thesaurus Code: C95020 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426555  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
177Lu-DOTA0-Tyr3-Octreotate
177 Lu-DOTA-TATE
177 Lu-DOTA-Tyr3-Octreotate
DOTATATE LUTENIUM LU-177
Lutathera
Lutetium Lu 177-DOTA-TATE
Lutetium Lu 177-DOTA-Tyr3-Octreotate
lutetium Lu 177-DOTATATE
Lutetium Lu 177 DOTA(0)-Tyr(3)-Octreotate
Lutetium Lu 177 Dotatate

External Source Codes: 
CAS Registry Number 437608-50-9 (see NLM ChemIDplus info)
FDA UNII Code AE221IM3BB
PDQ Closed Trial Search ID 689409
PDQ Open Trial Search ID 689409 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 18649310 (see PubMed Primary Reference info)
PubMedID Primary Reference 20168290 (see PubMed Primary Reference info)
NCI META CUI CL426555

Other Properties:
     Name Value (qualifiers indented underneath)
code C95020
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95020

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