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Version: 16.10e (Release date: 2016-10-31)
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Zidovudine (Code C947)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Zidovudine

Definition: A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. (NCI04)

NCI-GLOSS Definition: A drug that inhibits the human immunodeficiency virus (HIV) that causes AIDS. It is a type of systemic antiviral.

Display Name: Zidovudine

Label: Zidovudine

NCI Thesaurus Code: C947 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0043474  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)-5-methylpyrimidine-2,4-(1H,3H)-dione
3'-Azido-3'-deoxythymidine
Azidothymidine
AZT
Aztec
BW-A509U
BW-A 509U
BW A509U
Compound S
DRG-0004
Retrovir
ZDV
Zidovudine
ZIDOVUDINE
zidovudine

External Source Codes: 
CAS Registry Number 30516-87-1 (see NLM ChemIDplus info)
FDA UNII Code 4B9XT59T7S
ChEBI ID CHEBI:10110 (see ChEBI info)
NSC Code 602670 (see NCI DTP info)
PDQ Closed Trial Search ID 40121
PDQ Open Trial Search ID 40121 (check for NCI PDQ open clinical trial info)
UMLS CUI C0043474

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For AIDs-related complex; HIV infection; HIV transmission, prevention
Chemical_Formula C10H13N5O4
code C947
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Zidovudine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C947

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