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Version: 17.06d (Release date: 2017-06-26)
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Warfarin (Code C945)

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Terms & Properties

Preferred Name: Warfarin

Definition: A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.

NCI-GLOSS Definition: A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).

Display Name: Warfarin

Label: Warfarin

NCI Thesaurus Code: C945 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0043031  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin
3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin
3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin
3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
Athrombin-K
Co-Rax
Compound 42
Rodex
Warfarin
WARFARIN
warfarin
WARF compound 42
WARF Compound 42

External Source Codes: 
CAS Registry Number 81-81-2 (see NLM ChemIDplus info)
FDA UNII Code 5Q7ZVV76EI
ChEBI ID CHEBI:10033 (see ChEBI info)
NSC Code 59813 (see NCI DTP info)
PDQ Closed Trial Search ID 39740
PDQ Open Trial Search ID 39740 (check for NCI PDQ open clinical trial info)
UMLS CUI C0043031

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Pulmonary embolism and thromboembolic disorders, treatment and prophylaxis; Venous thrombosis, prophylaxis and treatment
Chemical_Formula C19H16O4
code C945
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Warfarin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C945

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