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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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HDAC inhibitor CG200745 (Code C94225)

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Terms & Properties

Preferred Name: HDAC inhibitor CG200745

Definition: A histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. CG200745 inhibits the catalytic activity of HDAC, resulting in an accumulation of highly acetylated chromatin histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. In particular, this agent enhances the histone acetylation of the tumor suppressor gene p53. This results in an accumulation of p53, p53-dependent transactivation and apoptosis in tumor cells. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins.

Label: HDAC inhibitor CG200745

NCI Thesaurus Code: C94225 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3492625  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HDAC inhibitor CG200745

External Source Codes: 
PDQ Closed Trial Search ID 688308
PDQ Open Trial Search ID 688308 (check for NCI PDQ open clinical trial info)
UMLS CUI C3492625

Other Properties:
     Name Value (qualifiers indented underneath)
code C94225
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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