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Version: 17.06d (Release date: 2017-06-26)
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BRAF Inhibitor ARQ 736 (Code C94224)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: BRAF Inhibitor ARQ 736

Definition: An orally bioavailable, highly soluble phosphate prodrug of B-raf (BRAF) protein kinase with potential antineoplastic activity. BRAF inhibitor ARQ 736 is converted into its active form ARQ 680 in the presence of phosphatases. In turn, ARQ 680 selectively binds to and inhibits the activity of oncogenic B-raf, which may inhibit the proliferation of tumor cells expressing mutated B-raf gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. The valine to glutamic acid substitution at residue 600 (V600E) accounts for about 90% of BRAF gene mutations.

Display Name: BRAF Inhibitor ARQ 736

Label: BRAF Inhibitor ARQ 736

NCI Thesaurus Code: C94224 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433988  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AQ 736
BRAF Inhibitor ARQ 736

External Source Codes: 
PDQ Closed Trial Search ID 688029
PDQ Open Trial Search ID 688029 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433988

Other Properties:
     Name Value (qualifiers indented underneath)
code C94224
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C94224

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