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Version: 16.11d (Release date: 2016-11-28)
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GITRL RNA-transfected Autologous Dendritic Cell Vaccine (Code C94216)

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Terms & Properties

Preferred Name: GITRL RNA-transfected Autologous Dendritic Cell Vaccine

Definition: An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. GITRL RNA-transfected autologous DC vaccine is prepared by transfecting DCs with RNAs encoding tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of GlTRL results in modulating T lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses.

Display Name: GITRL RNA-transfected Autologous Dendritic Cell Vaccine

Label: GITRL RNA-transfected Autologous Dendritic Cell Vaccine

NCI Thesaurus Code: C94216 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426029  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GITRL RNA-transfected Autologous DC
GITRL RNA-transfected Autologous Dendritic Cell Vaccine
GITRL RNA DC

External Source Codes: 
PDQ Closed Trial Search ID 687562
PDQ Open Trial Search ID 687562 (check for NCI PDQ open clinical trial info)
NCI META CUI CL426029

Other Properties:
Name Value (qualifiers indented underneath)
code C94216
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C94216

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