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Version: 17.06d (Release date: 2017-06-26)
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Indoleamine 2,3-dioxygenase Peptide Vaccine (Code C94215)

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Terms & Properties

Preferred Name: Indoleamine 2,3-dioxygenase Peptide Vaccine

Definition: A peptide vaccine against the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO), with potential immunomodulating and antineoplastic activities. Vaccination with indoleamine 2,3-dioxygenase peptide vaccine may activate the immune system to induce an immune response against IDO-expressing cells. This may increase and restore the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T-lymphocytes, and may eradicate IDO-expressing tumor cells. IDO, a cytosolic enzyme responsible for tryptophan catabolism and conversion of tryptophan into kynurenine, is overexpressed by a variety of tumor cell types and antigen presenting cells (APCs) and plays an important role in immunosuppression; Tryptophan depletion inhibits T-lymphocyte proliferation and activation, and suppresses the immune system.

Label: Indoleamine 2,3-dioxygenase Peptide Vaccine

NCI Thesaurus Code: C94215 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426028  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IDO Peptide Vaccine
Indoleamine 2,3-dioxygenase Peptide Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 687432
PDQ Open Trial Search ID 687432 (check for NCI PDQ open clinical trial info)
NCI META CUI CL426028

Other Properties:
     Name Value (qualifiers indented underneath)
code C94215
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C94215

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