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Version: 17.06d (Release date: 2017-06-26)
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Alpelisib (Code C94214)

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Terms & Properties

Preferred Name: Alpelisib

Definition: An orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Alpelisib specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Display Name: Alpelisib

Label: Alpelisib

NCI Thesaurus Code: C94214 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2986399  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alpelisib
BYL719
Phosphoinositide 3-kinase Inhibitor BYL719

External Source Codes: 
PDQ Closed Trial Search ID 687431
PDQ Open Trial Search ID 687431 (check for NCI PDQ open clinical trial info)
UMLS CUI C2986399

Other Properties:
     Name Value (qualifiers indented underneath)
code C94214
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C94214

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