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Version: 17.08d (Release date: 2017-08-28)
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Choline Kinase Alpha Inhibitor TCD-717 (Code C94213)

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Terms & Properties

Preferred Name: Choline Kinase Alpha Inhibitor TCD-717

Definition: A small-molecule inhibitor of choline kinase alpha (CHKA), with potential antineoplastic activity. TCD-717 targets and binds to CHKA, an enzyme that plays a key role in the synthesis of phosphatidylcholine, the major phospholipid in eukaryotic cell membranes. Blockade of this enzyme induces cells to activate a different route for phospholipid production which causes a toxic effect and eventually leads to cell destruction. CHKA, overexpressed in human cancer cells while only minimally expressed in normal cells, appears to play a significant role in cellular proliferation, evasion of apoptosis, increased cell motility and metastasis.

Display Name: Choline Kinase Alpha Inhibitor TCD-717

Label: Choline Kinase Alpha Inhibitor TCD-717

NCI Thesaurus Code: C94213 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426026  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CHKA Inhibitor TCD-717
Choline Kinase Alpha Inhibitor TCD-717

External Source Codes: 
PDQ Closed Trial Search ID 687183
PDQ Open Trial Search ID 687183 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C94213
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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