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Version: 17.06d (Release date: 2017-06-26)
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Glioblastoma Multiforme Multipeptide Vaccine IMA950 (Code C94211)

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Terms & Properties

Preferred Name: Glioblastoma Multiforme Multipeptide Vaccine IMA950

Definition: A cancer vaccine comprised of 11 peptides associated with glioblastoma multiforme (GBM), with potential immunomodulating and antineoplastic activities. Vaccination with glioblastoma multiforme multi-antigen vaccine IMA950 stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response as well as a T-helper (Th) immune response against tumor cells expressing these peptides, potentially resulting in decreased tumor growth of GBM. Peptides in IMA950 consist of the following: brevican (BCAN); chondroitin sulfate proteoglycan 4 (CSPG4); fatty acid binding protein 7, brain (FABP7); insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3); neuroligin 4, X-linked (NLGN4X); neuronal cell adhesion molecule (NRCAM); protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1); tenascin C (TNC); Met proto-oncogene (MET); baculoviral IAP repeat-containing 5 (BIRC5); and hepatitis B virus core antigen.

Display Name: Glioblastoma Multiforme Multipeptide Vaccine IMA950

Label: Glioblastoma Multiforme Multipeptide Vaccine IMA950

NCI Thesaurus Code: C94211 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426024  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Glioblastoma Multiforme Multipeptide Vaccine IMA950
IMA950

External Source Codes: 
PDQ Closed Trial Search ID 687015
PDQ Open Trial Search ID 687015 (check for NCI PDQ open clinical trial info)
NCI META CUI CL426024

Other Properties:
     Name Value (qualifiers indented underneath)
code C94211
Contributing_Source CTRP
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C94211

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