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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Human Fusion Protein L19TNFalpha (Code C94210)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Recombinant Human Fusion Protein L19TNFalpha

Definition: An immunocytokine consisting of human pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha) fused to a human single-chain variable fragment (scFv) directed against the extra-domain B (ED-B) of fibronectin (L19), with potential immunopotentiating and antineoplastic activities. The L19 moiety of recombinant human fusion protein L19TNFalpha binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature. In turn, the TNFalpha moiety may locally induce an immune response against ED-B fibronectin-expressing tumor cells and may specifically decrease the proliferation of ED-B-expressing tumor cells. ED-B is predominantly expressed during angiogenesis and tumor growth.

Label: Recombinant Human Fusion Protein L19TNFalpha

NCI Thesaurus Code: C94210 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL426023  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L19-TNF-alpha
Recombinant Human Fusion Protein L19TNFalpha

External Source Codes: 
PDQ Closed Trial Search ID 686947
PDQ Open Trial Search ID 686947 (check for NCI PDQ open clinical trial info)
NCI META CUI CL426023

Other Properties:
     Name Value (qualifiers indented underneath)
code C94210
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C94210

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