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Version: 17.06d (Release date: 2017-06-26)
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Vitamin E Compound (Code C942)

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Terms & Properties

Preferred Name: Vitamin E Compound

Definition: A natural fat-soluble antioxidant with potential chemopreventive activity. Also known as tocopherol, vitamin E ameliorates free-radical damage to biological membranes, protecting polyunsaturated fatty acids (PUFA) within membrane phospholipids and within circulating lipoproteins. Peroxyl radicals react 1000-fold faster with vitamin E than with PUFA. In the case of oxygen free radical-mediated tumorigenesis, vitamin E may be chemopreventive. (NCI04)

NCI-GLOSS Definition: A nutrient that the body needs in small amounts to function and stay healthy. Vitamin E helps prevent cell damage caused by free radicals (highly reactive chemicals). It is fat-soluble (can dissolve in fats and oils) and is found in seeds, nuts, leafy vegetables, and vegetable oils. Not enough vitamin E can result in infertility (the inability to produce children). It is being studied in the prevention and treatment of some types of cancer. Vitamin E is a type of antioxidant.

CRCH Definition: A fat-soluble vitamin which is primarily a chain-breaking antioxidant that prevents the propagation of lipid peroxidation.

Display Name: Vitamin E Compound

Label: Vitamin E Compound

NCI Thesaurus Code: C942 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0042874  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol
5,7,8-Trimethyltocol
E Vitamin
vitamin E
Vitamin E
Vitamin E Compound

External Source Codes: 
CAS Registry Number 1406-18-4 (see NLM ChemIDplus info)
ChEBI ID CHEBI:33234 (see ChEBI info)
NSC Code 20812 (see NCI DTP info)
PDQ Closed Trial Search ID 38321
PDQ Open Trial Search ID 38321 (check for NCI PDQ open clinical trial info)
UMLS CUI C0042874

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Vitamin E deficiency
code C942
Contributing_Source CRCH
Contributing_Source CTRP
Legacy_Concept_Name Vitamin_E
Micronutrient Y
Nutrient Y
Semantic_Type Pharmacologic Substance
Semantic_Type Vitamin
Tolerable_Level Y
Unit mg
US_Recommended_Intake Y

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C942

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