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Version: 16.10e (Release date: 2016-10-31)
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Cobalamin (Code C939)

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Terms & Properties

Preferred Name: Cobalamin

Definition: An essential nutrient and natural water-soluble vitamin of the B-complex family that must combine with an intrinsic factor for absorption by the intestine, Vitamin B12 (cyanocobalamin) is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. B12 improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. B12 metabolism is interconnected with that of folic acid. Vitamin B12 deficiency causes pernicious anemia, megaloblastic anemia, and neurologic lesions.

NCI-GLOSS Definition: A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Vitamin B12 helps make red blood cells, DNA, RNA, energy, and tissues, and keeps nerve cells healthy. It is found in liver, meat, eggs, poultry, shellfish, milk, and milk products. Vitamin B12 is water-soluble (can dissolve in water) and must be taken in every day. Not enough vitamin B12 can cause certain types of anemia (a condition in which the number of red blood cells is below normal) and neurologic disorders. It is being studied with folate in the prevention and treatment of some types of cancer.

CRCH Definition: Cobalt-containing water soluble vitamin that is a coenzyme in the metabolism of fatty acids of odd-chain length and in methyl transfer. (DRI)

Display Name: Cobalamin

Label: Cobalamin

NCI Thesaurus Code: C939 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0042845  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B12 Vitamin
Cobalamin
COBALAMIN
cobalamin
Cobalamin (1+)
Vitamin-B12
Vitamin B-12
Vitamin B12
vitamin B12
VIT B12

External Source Codes: 
CAS Registry Number 13408-78-1 (see NLM ChemIDplus info)
FDA UNII Code 8406EY2OQA
ChEBI ID CHEBI:28911 (see ChEBI info)
ChEBI ID CHEBI:30411 (see ChEBI info)
PDQ Closed Trial Search ID 530928
PDQ Open Trial Search ID 530928 (check for NCI PDQ open clinical trial info)
UMLS CUI C0042845

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C62H88N13O14P.Co
code C939
Contributing_Source CRCH
Contributing_Source CTRP
Contributing_Source FDA
INFOODS VITAB12
Legacy_Concept_Name Vitamin_B12
Micronutrient Y
Nutrient Y
Semantic_Type Pharmacologic Substance
Semantic_Type Vitamin
Unit mcg
US_Recommended_Intake Y
USDA_ID 481

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C939

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