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Version: 16.10e (Release date: 2016-10-31)
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Vindesine (Code C934)

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Terms & Properties

Preferred Name: Vindesine

Definition: A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of plant drugs called vinca alkaloids.

Label: Vindesine

NCI Thesaurus Code: C934 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0042682  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-(Aminocarbonyl)-O4-deacetyl-3-de-(methoxycarbonyl)vincaleukoblastine
Compound 112531
DAVA
Deacetylvinblastine Carboxamide
Deacetyl Vinblastine Carboxamide
Desacetylvinblastine Amide
DVA
Lilly CT-3231
VDS
VINDESINE
Vindesine
vindesine

External Source Codes: 
CAS Registry Number 53643-48-4 (see NLM ChemIDplus info)
FDA UNII Code RSA8KO39WH
ChEBI ID CHEBI:36373 (see ChEBI info)
PDQ Closed Trial Search ID 39732
PDQ Open Trial Search ID 39732 (check for NCI PDQ open clinical trial info)
UMLS CUI C0042682

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C43H55N5O7
code C934
Contributing_Source FDA
Legacy_Concept_Name Vindesine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C934

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