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Version: 17.12d (Release date: 2017-12-26)
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Vinblastine (Code C930)

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Terms & Properties

Preferred Name: Vinblastine

Definition: A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)

NCI-GLOSS Definition: The active ingredient in a drug used together with other drugs to treat several types of cancer, including advanced Hodgkin lymphoma and advanced testicular germinal-cell cancers. It is also being studied in the treatment of other types of cancer. Vinblastine comes from the periwinkle plant Vinca rosea Linn. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of vinca alkaloid and a type of antimitotic agent.

Display Name: Vinblastine

Label: Vinblastine

NCI Thesaurus Code: C930 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0042670  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 865-21-4 (see NLM ChemIDplus info)
ChEBI ID CHEBI:27375 (see ChEBI info)
NSC Code 90636 (see NCI DTP info)
PDQ Closed Trial Search ID 42951
PDQ Open Trial Search ID 42951 (check for NCI PDQ open clinical trial info)
UMLS CUI C0042670

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Bladder cancer; Breast cancer; Choriocarcinoma; Germ cell tumors; Idiopathic thrombocytopenic purpura; Kaposi sarcoma; Letterer-Siwe disease; Various Lymphomas; Melanoma; Mycosis fungoides; Prostate cancer; Testicular cancer
Chemical_Formula C46H58N4O9
code C930
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Vinblastine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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