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Version: 17.06d (Release date: 2017-06-26)
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Verapamil (Code C928)

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Terms & Properties

Preferred Name: Verapamil

Definition: A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

Display Name: Verapamil

Label: Verapamil

NCI Thesaurus Code: C928 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0042523  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
Verapamil
VERAPAMIL

External Source Codes: 
CAS Registry Number 52-53-9 (see NLM ChemIDplus info)
FDA UNII Code CJ0O37KU29
ChEBI ID CHEBI:9948 (see ChEBI info)
PDQ Closed Trial Search ID 39730
PDQ Open Trial Search ID 39730 (check for NCI PDQ open clinical trial info)
UMLS CUI C0042523

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H38N2O4
code C928
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Verapamil
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C928

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