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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Thiarabine (Code C92589)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Thiarabine

Definition: A analog of antimetabolite cytarabine (ara-C), with potential antineoplastic activity. Upon administration, thiarabine (T-araC) is phosphorylated to the triphosphate form T-araCTP and competes with cytidine for incorporation into DNA. This results in an inhibition of DNA replication and RNA synthesis, chain termination and may eventually decrease tumor cell proliferation. Compared to ara-C, T-araC appears to have a longer half-life and has a higher efficacy.

Display Name: Thiarabine

Label: Thiarabine

NCI Thesaurus Code: C92589 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0915967  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-thio-araC
Thiarabine

External Source Codes: 
PDQ Closed Trial Search ID 675426
PDQ Open Trial Search ID 675426 (check for NCI PDQ open clinical trial info)
UMLS CUI C0915967

Other Properties:
     Name Value (qualifiers indented underneath)
code C92589
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C92589

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