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Version: 16.11d (Release date: 2016-11-28)
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E. coli CD-expressing Genetically Modified Neural Stem Cells (Code C92585)

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Terms & Properties

Preferred Name: E. coli CD-expressing Genetically Modified Neural Stem Cells

Definition: Genetically-modified neural stem cells (NSCs) transfected with the Escherichia coli (E. coli) suicidal gene cytosine deaminase (CD), with potential antineoplastic adjuvant activity. Upon intracerebral injection, E. coli CD-expressing genetically modified NSCs express the E. coli cytosine deaminase, an enzyme that catalyzes the intracellular conversion of the nontoxic prodrug 5-fluorocytosine (5-FC) into the cytotoxic 5-fluorouracil (5-FU). Co-administration of this agent with 5-FC and upon local activation of 5-FU in the brain tumor, 5-FU disrupts DNA synthesis in tumor cells thereby impeding cellular proliferation with minimal systemic exposure and toxicity.

Display Name: E. coli CD-expressing Genetically Modified Neural Stem Cells

Label: E. coli CD-expressing Genetically Modified Neural Stem Cells

NCI Thesaurus Code: C92585 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421632  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
E. coli CD-expressing Genetically Modified Neural Stem Cells

External Source Codes: 
PDQ Closed Trial Search ID 680811
PDQ Open Trial Search ID 680811 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421632

Other Properties:
Name Value (qualifiers indented underneath)
code C92585
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C92585

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